| First Author | Ichikawa H | Year | 2005 |
| Journal | Brain Res | Volume | 1053 |
| Issue | 1-2 | Pages | 203-6 |
| PubMed ID | 16040009 | Mgi Jnum | J:100128 |
| Mgi Id | MGI:3587126 | Doi | 10.1016/j.brainres.2005.06.026 |
| Citation | Ichikawa H, et al. (2005) Brn-3a is required for the generation of proprioceptors in the mesencephalic trigeminal tract nucleus. Brain Res 1053(1-2):203-6 |
| abstractText | The distribution of motor and proprioceptive neurons was investigated in the trigeminal nervous system of wild-type and Brn-3a knockout mice at embryonic day 18.5 and postnatal day 0. We found that the trigeminal motor nucleus (Mo5) contained abundant motoneurons in wild-type (mean number +/- SD per section = 128 +/- 22, range = 93-167) and knockout (mean number +/- SD per section = 121 +/- 23, range = 75-158) mice and that the cell size of Mo5 neurons was similar between these mice (wild-type, mean +/- SD = 165 +/- 59 microm2, range = 65-326 microm2; knockout, mean +/- SD = 167 +/- 59 microm2, range = 71-327 microm2). Mo5 neurons were immunoreactive for calcitonin gene-related peptide and such immunoreactive neurons were abundant in both wild-type and mutant mice. In the mesencephalic tract nucleus (Mes5) of wild-type mice, many proprioceptors (mean number +/- SD per section = 56 +/- 19, range = 27-85) that contained parvalbumin immunoreactivity were also observed. In knockout mice, however, Mes5 neurons could not be detected. The area of brainstems which normally contained the Mes5 was devoid of parvalbumin-immunoreactive proprioceptors. The present study suggests that Brn-3a is required for the development of proprioceptors but not motoneurons in the trigeminal nervous system. |
