| First Author | Inoue T | Year | 2001 |
| Journal | Development | Volume | 128 |
| Issue | 4 | Pages | 561-9 |
| PubMed ID | 11171339 | Mgi Jnum | J:67150 |
| Mgi Id | MGI:1929968 | Doi | 10.1242/dev.128.4.561 |
| Citation | Inoue T, et al. (2001) Role of cadherins in maintaining the compartment boundary between the cortex and striatum during development. Development 128(4):561-9 |
| abstractText | In ventricular cells of the mouse telencephalon, differential expression of cadherin cell adhesion molecules defines neighbouring regions; R-cadherin delineates the future cerebral cortex, while cadherin-6 delineates the lateral ganglionic eminence. By using cell labelling analyses in the whole embryo culture system, we demonstrated that the interface between R-cadherin and cadherin-6 expression is a boundary for cell lineage restriction at embryonic day 10.5. Interestingly, when a group of cells with exogenous cadherin-6 were generated to straddle the cortico-straital boundary by electroporation at embryonic day 11.0, ectopic cadherin-6-expressing cortical cells were sorted into the striatal compartment, and the reverse was the trend for ectopic R-cadherin-expressing striatal cells. Although cadherin-6 gene knockout mice engineered in this study showed no obvious phenotype in telencephalic compartmentalisation, the preferential sorting of ectopic cadherin-6-expressing cells was abolished in this mutant background. Thus, the differential expression pattern of cadherins in the embryonic telencephalon is responsible for maintaining the cortico-striatal compartment boundary. |
