| First Author | Westaway D | Year | 1991 |
| Journal | Neuron | Volume | 7 |
| Issue | 1 | Pages | 59-68 |
| PubMed ID | 1676894 | Mgi Jnum | J:11316 |
| Mgi Id | MGI:59753 | Doi | 10.1016/0896-6273(91)90074-a |
| Citation | Westaway D, et al. (1991) Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice. Neuron 7(1):59-68 |
| abstractText | Prolonged incubation times for experimental scrapie in I/LnJ mice are dictated by a dominant gene linked to the prion protein gene (Prn-p). Transgenic mice were analyzed to discriminate between an effect of the I/LnJ Prn-pb allele and a distinct incubation time locus designated Prn-i. Paradoxically, 4 independent Prn-pb transgenic mouse lines had scrapie incubation times shorter than nontransgenic controls, instead of the anticipated prolonged incubation periods. Aberrant or overexpression of the Prn-pb transgenes may dictate abbreviated incubation times, masking genuine Prn-p/Prn-i congruence; alternatively, a discrete Prn-i gene lies adjacent to Prn-p. |
