| Primary Identifier | MGI:2387688 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Prnp |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The gene was disrupted by insertion of a neomycin resistance cassette (under the control of a mouse metallothionein promoter) into exon 3. Northern blot analysis of brain mRNA from homozygous mutant animals did not detect gene transcript, but detected the neo transcript. Western blot of brain membrane fractions from homozygous animals further confirmed the null allele. |
