| First Author | Sanchez-Alavez M | Year | 2008 |
| Journal | Neuroreport | Volume | 19 |
| Issue | 15 | Pages | 1473-7 |
| PubMed ID | 18797300 | Mgi Jnum | J:143103 |
| Mgi Id | MGI:3822933 | Doi | 10.1097/WNR.0b013e32830f1e90 |
| Citation | Sanchez-Alavez M, et al. (2008) Hypothalamic-pituitary-adrenal axis disregulation in PrPC-null mice. Neuroreport 19(15):1473-7 |
| abstractText | As manifestations of prion diseases include disturbances of hypothalamic and pituitary functions, we tested the hypothesis that the cellular prion protein (PrPC) has a role as modulator of the hypothalamic-pituitary-adrenal axis. The level of corticosterone and adrenocorticotropic hormone were compared in PrPC null (PrP 0/0) and wild-type (PrP+/+) mice. PrP 0/0 showed hypercorticism during the dark part of day. After acute stress, corticosterone and adrenocorticotropic hormone increased similarly in PrP+/+ and PrP 0/0 mice. Adrenocorticotropic hormone, however, remained elevated in PrP+/+ 0/0 mice at corticosterone levels that are inhibitory in PrP mice. Pretreatment with corticosterone or dexamethasone inhibited stress-induced elevation of adrenocorticotropic hormone in PrP+/+ but not in PrP 0/0 mice. Thus, PrPC may play a role in the negative feedback regulation of axis. |
