| First Author | Chesebro B | Year | 2005 |
| Journal | Science | Volume | 308 |
| Issue | 5727 | Pages | 1435-9 |
| PubMed ID | 15933194 | Mgi Jnum | J:140306 |
| Mgi Id | MGI:3813224 | Doi | 10.1126/science.1110837 |
| Citation | Chesebro B, et al. (2005) Anchorless prion protein results in infectious amyloid disease without clinical scrapie. Science 308(5727):1435-9 |
| abstractText | In prion and Alzheimer's diseases, the roles played by amyloid versus nonamyloid deposits in brain damage remain unresolved. In scrapie-infected transgenic mice expressing prion protein (PrP) lacking the glycosylphosphatidylinositol (GPI) membrane anchor, abnormal protease-resistant PrPres was deposited as amyloid plaques, rather than the usual nonamyloid form of PrPres. Although PrPres amyloid plaques induced brain damage reminiscent of Alzheimer's disease, clinical manifestations were minimal. In contrast, combined expression of anchorless and wild-type PrP produced accelerated clinical scrapie. Thus, the PrP GPI anchor may play a role in the pathogenesis of prion diseases. |
