| First Author | Yamada K | Year | 2000 |
| Journal | Physiol Behav | Volume | 68 |
| Issue | 4 | Pages | 555-61 |
| PubMed ID | 10713297 | Mgi Jnum | J:96589 |
| Mgi Id | MGI:3530997 | Doi | 10.1016/s0031-9384(99)00214-0 |
| Citation | Yamada K, et al. (2000) Differential effects of social isolation upon body weight, food consumption, and responsiveness to novel and social environment in bombesin receptor subtype-3 (BRS-3) deficient mice. Physiol Behav 68(4):555-61 |
| abstractText | The effects of social isolation on body weight gain, food consumption, and responsiveness to novel and social environment were assessed in an animal model for obesity, bombesin receptor subtype-3 (BRS-3) deficient mice. In Experiment 1, body weight gain and food consumption of group- and isolation-housed wild-type and BRS-3-deficient mice were compared. In wild-type mice, group-housed animals showed greater mean body weight gain and food consumption than did the isolation-housed cohort in the early stage of the experiment, whereas in BRS-3-deficient mice, the isolation-housed mice showed greater body weight gain and food consumption than the group-housed cohort by prolonged isolation housing. In Experiment 2, isolation-housed wild-type mice exhibited increased stereotypic and vertical movements relative to group-housed subjects in a novel environment, but this effect was not observed in BRS-3-deficient mice. In Experiment 3, when social response was assessed in animals housed in isolation, BRS-3-deficient mice exhibited lower social responses than did wild-type mice. We conclude that BRS-3-deficient mice and wild-type mice are differentially affected by social isolation. These results suggest that BRS-3 expression in the CNS may affect the neural mechanisms that regulate isolation effects in wild-type animals. |
