| First Author | Sussman MA | Year | 1998 |
| Journal | Science | Volume | 281 |
| Issue | 5383 | Pages | 1690-3 |
| PubMed ID | 9733519 | Mgi Jnum | J:49872 |
| Mgi Id | MGI:1289346 | Doi | 10.1126/science.281.5383.1690 |
| Citation | Sussman MA, et al. (1998) Prevention of cardiac hypertrophy in mice by calcineurin inhibition [see comments]. Science 281(5383):1690-3 |
| abstractText | Hypertrophic cardiomyopathy (HCM) is an inherited form of heart disease that affects 1 in 500 individuals. Here it is shown that calcineurin, a calcium-regulated phosphatase, plays a critical role in the pathogenesis of HCM. Administration of the calcineurin inhibitors cyclosporin and FK506 prevented disease in mice that were genetically predisposed to develop HCM as a result of aberrant expression of tropomodulin, myosin light chain-2, or fetal beta-tropomyosin in the heart. Cyclo-sporin had a similar effect in a rat model of pressure-overload hypertrophy. These results suggest that calcineurin inhibitors merit investigation as potential therapeutics for certain forms of human heart disease. |
