| Primary Identifier | MGI:2387409 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Timp3 |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The gene was disrupted by replacement of part of exon 1 (just upstream of the translation initiation codon) to part of exon 2 (after the conserved VIRAK codons) with a neomycin resistance cassette in the reverse orientation. Northern blot of lung, kidney, and heart RNA and RT-PCR analysis did not detect gene expression in homozygous mutants. Reverse zymographic analysis of kidney extracts did not detect protein activity in homozygous animals. |
