| First Author | Szabo GG | Year | 2022 |
| Journal | Neuron | Volume | 110 |
| Issue | 12 | Pages | 1959-1977.e9 |
| PubMed ID | 35489331 | Mgi Jnum | J:330685 |
| Mgi Id | MGI:7311505 | Doi | 10.1016/j.neuron.2022.04.002 |
| Citation | Szabo GG, et al. (2022) Ripple-selective GABAergic projection cells in the hippocampus. Neuron 110(12):1959-1977.e9 |
| abstractText | Ripples are brief high-frequency electrographic events with important roles in episodic memory. However, the in vivo circuit mechanisms coordinating ripple-related activity among local and distant neuronal ensembles are not well understood. Here, we define key characteristics of a long-distance projecting GABAergic cell group in the mouse hippocampus that selectively exhibits high-frequency firing during ripples while staying largely silent during theta-associated states when most other GABAergic cells are active. The high ripple-associated firing commenced before ripple onset and reached its maximum before ripple peak, with the signature theta-OFF, ripple-ON firing pattern being preserved across awake and sleep states. Controlled by septal GABAergic, cholinergic, and CA3 glutamatergic inputs, these ripple-selective cells innervate parvalbumin and cholecystokinin-expressing local interneurons while also targeting a variety of extra-hippocampal regions. These results demonstrate the existence of a hippocampal GABAergic circuit element that is uniquely positioned to coordinate ripple-related neuronal dynamics across neuronal assemblies. |
