Primary Identifier | MGI:2387765 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Mertk |
Inheritance Mode | Not Specified | Transmission | Germline |
Strain of Origin | 129P2/OlaHsd | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A neomycin selection cassette replaced a genomic fragment containing exon 18 of the gene, which encodes part of the kinase domain known to be essential for tyrosine kinase function. An RNase protection assay demonstrated that a mutant transcript was expressed that lacked the deleted sequences. |