| First Author | Cohen PL | Year | 2002 |
| Journal | J Exp Med | Volume | 196 |
| Issue | 1 | Pages | 135-40 |
| PubMed ID | 12093878 | Mgi Jnum | J:77492 |
| Mgi Id | MGI:2181886 | Doi | 10.1084/jem.20012094 |
| Citation | Cohen PL, et al. (2002) Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. J Exp Med 196(1):135-40 |
| abstractText | Mice lacking the membrane tyrosine kinase c-mer have been shown to have altered macro-phage cytokine production and defective phagocytosis of apoptotic cells despite normal phagocytosis of other particles. We show here that c-mer-deficient mice have impaired clearance of infused apoptotic cells and that they develop progressive lupus-like autoimmunity, with antibodies to chromatin, DNA, and IgG. The autoimmunity appears to be driven by endogenous antigens, with little polyclonal B cell activation. These mice should be an excellent model for studying the role of apoptotic debris as an immunogenic stimulus for systemic autoimmunity. |
