| First Author | Lüthi A | Year | 1997 |
| Journal | J Neurosci | Volume | 17 |
| Issue | 12 | Pages | 4688-99 |
| PubMed ID | 9169529 | Mgi Jnum | J:40953 |
| Mgi Id | MGI:892672 | Doi | 10.1523/JNEUROSCI.17-12-04688.1997 |
| Citation | Luthi A, et al. (1997) Endogenous serine protease inhibitor modulates epileptic activity and hippocampal long-term potentiation. J Neurosci 17(12):4688-99 |
| abstractText | Protease nexin-1 (PN-1), a member of the serpin superfamily, controls the activity of extracellular serine proteases and is expressed in the brain. Mutant mice overexpressing PN-1 in brain under the control of the Thy-1 promoter (Thy 1/PN-1) or lacking PN-1 (PN-1-/-) were found to develop epileptic activity in vivo and in vitro. Theta burst-induced long-term potentiation (LTP) and NMDA receptor-mediated synaptic transmission in the CA1 field of hippocampal slices were augmented in Thy 1/PN-1 mice and reduced in PN-1-/- mice. Compensatory changes in GABA-mediated inhibition in Thy 1/PN-1 mice suggest that altered brain PN-1 levels lead to an imbalance between excitatory and inhibitory synaptic transmission. |
