| First Author | Yu H | Year | 2020 |
| Journal | Oxid Med Cell Longev | Volume | 2020 |
| Pages | 5602396 | PubMed ID | 32850000 |
| Mgi Jnum | J:313544 | Mgi Id | MGI:6795996 |
| Doi | 10.1155/2020/5602396 | Citation | Yu H, et al. (2020) O-GlcNAcylation Is Essential for Autophagy in Cardiomyocytes. Oxid Med Cell Longev 2020:5602396 |
| abstractText | Since both O-GlcNAcylation and autophagy sense intracellular nutrient level, the alteration of those two pathways plays substantial roles in the progression of heart failure. Hence, determining the relationship between O-GlcNAcylation and autophagy is imperative to understand, prevent, and treat heart failure. However, the mechanism on how O-GlcNAcylation regulates autophagy in the heart is poorly investigated. In this study, we demonstrated that O-GlcNAcylation is required for autophagy in cardiomyocytes by utilizing an O-linked beta-N-acetylglucosamine transferase (OGT) cardiomyocyte-specific knockout mouse model for the first time. We also identified that OGT might regulate the initiation of autophagy in cardiomyocytes through promoting the activity of ULK1 by O-GlcNAcylation. In conclusion, our findings provide new insights into the molecular mechanisms underlying heart dysfunction and benefit the development of treatments for heart failure. |
