| First Author | Ferris CD | Year | 1999 |
| Journal | Nat Cell Biol | Volume | 1 |
| Issue | 3 | Pages | 152-7 |
| PubMed ID | 10559901 | Mgi Jnum | J:59677 |
| Mgi Id | MGI:1352047 | Doi | 10.1038/11072 |
| Citation | Ferris CD, et al. (1999) Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol 1(3):152-7 |
| abstractText | Haem oxygenase-1 (HO1) is a heat-shock protein that is induced by stressful stimuli. Here we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1. Iron efflux from cells is augmented by HO1 transfection and reduced in HO1-deficient fibroblasts. Iron accumulation in HO1-deficient cells explains their death: iron chelators protect HO1-deficient fibroblasts from cell death. Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability. |
