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Allele : H2-Ab1<b-tm1Hpl> histocompatibility 2, class II antigen A, beta 1; targeted mutation 1, Hidde Ploegh

Primary Identifier  MGI:2387946 Allele Type  Targeted
Attribute String  Reporter Gene  H2-Ab1
Transmission  Germline Strain of Origin  129S4/SvJae
Is Recombinase  false Is Wild Type  false
description  J1 ES cells carry the b-haplotype of H2, which carries a mutation in the Ea promoter preventing the cell surface expression of the I-E complex.
molecularNote  This allele encodes an intact class II beta chain with an EGFP moiety fused to the carboxy terminal. The fusion protein was detected in whole spleen lysates, whereas free EGFP was not. An intronic floxed neo cassette upstream of the 3' untranslated region was included for selection.
  • mutations:
  • Insertion
  • synonyms:
  • I-A<b>-GFP,
  • MHC II-EGFP,
  • MHC II-EGFP,
  • MHCIIGFP,
  • H2-Ab1<tm1Hpl>,
  • H2-Ab1<tm1Hpl>,
  • I-A<b>-GFP,
  • MHCIIGFP,
  • MHCII-EGFP,
  • MHCII-EGFP
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

35 Publication categories