| First Author | Ghazvini M | Year | 2002 |
| Journal | EMBO J | Volume | 21 |
| Issue | 17 | Pages | 4612-20 |
| PubMed ID | 12198163 | Mgi Jnum | J:78939 |
| Mgi Id | MGI:2386505 | Doi | 10.1093/emboj/cdf475 |
| Citation | Ghazvini M, et al. (2002) A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration. EMBO J 21(17):4612-20 |
| abstractText | While an important role for the POU domain transcription factor Oct-6 in the developing peripheral nerve has been well established, studies into its exact role in nerve development and regeneration have been hampered by the high mortality rate of newborn Oct-6 mutant animals. In this study we have generated a Schwann cell-specific Oct-6 allele through deletion of the Schwann cell-specific enhancer element (SCE) in the Oct-6 locus. Analysis of mice homozygous for this allele (deltaSCE allele) reveals that rate-limiting levels of Oct-6 in Schwann cells are dependent on the SCE and that this element does not contribute to Oct-6 regulation in other cell types. We demonstrate a Schwann cell autonomous function for Oct-6 during nerve development as well as in regenerating nerve. Additionally, we show that Krox-20, an important regulatory target of Oct-6 in Schwann cells, is activated, with delayed kinetics, through an Oct-6-independent mechanism in these mice. |
