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Publication : Quantal noise from human red cone pigment.

First Author  Fu Y Year  2008
Journal  Nat Neurosci Volume  11
Issue  5 Pages  565-71
PubMed ID  18425122 Mgi Jnum  J:136254
Mgi Id  MGI:3795797 Doi  10.1038/nn.2110
Citation  Fu Y, et al. (2008) Quantal noise from human red cone pigment. Nat Neurosci 11(5):565-71
abstractText  The rod pigment, rhodopsin, shows spontaneous isomerization activity. This quantal noise produces a dark light of approximately 0.01 photons s(-1) rod(-1) in human, setting the threshold for rod vision. The spontaneous isomerization activity of human cone pigments has long remained a mystery because the effect of a single isomerized pigment molecule in cones, unlike that in rods, is small and beyond measurement. We have now overcome this problem by expressing human red cone pigment transgenically in mouse rods in order to exploit their large single-photon response, especially after genetic removal of a key negative-feedback regulation. Extrapolating the measured quantal noise of transgenic cone pigment to native human red cones, we obtained a dark rate of approximately 10 false events s(-1) cone(-1), almost 10(3)-fold lower than the overall dark transduction noise previously reported in primate cones. Our measurements provide a rationale for why mammalian red, green and blue cones have comparable sensitivities, unlike their amphibian counterparts.
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