| Primary Identifier | MGI:2388384 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Klk8 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The gene was disrupted by replacment of the region of exon 3 encoding the aspartic acid region of the catalytic site with a lacZ-neo cassette. The targeting construct introduces stop codons in all 3 reading frames. Northern blot analysis of brain RNA verified the absence of gene expression in homozygous mutant animals. X-gal staining of mutant brains did not detect any lacZ expression. |
