| First Author | Jung MY | Year | 1999 |
| Journal | J Biol Chem | Volume | 274 |
| Issue | 41 | Pages | 29406-12 |
| PubMed ID | 10506202 | Mgi Jnum | J:57972 |
| Mgi Id | MGI:1346258 | Doi | 10.1074/jbc.274.41.29406 |
| Citation | Jung MY, et al. (1999) Decreased c-fos responses to dopamine D(1) receptor agonist stimulation in mice deficient for D(3) receptors. J Biol Chem 274(41):29406-12 |
| abstractText | The acute administration of dopamine D(1) receptor agonists induces the expression of the immediate early gene c-fos. In wild type mice, this induction is completely abolished by pretreatment with the D(1)-selective antagonist SCH23390, and pretreatment with the D(2)-like receptor antagonist eticlopride reduces the levels of c-fos expressed in response to D(1) receptor stimulation. Mice deficient for the dopamine D(3) receptor express levels of D(1) agonist-stimulated c-fos immunoreactivity that are lower than c-fos levels of their wild type littermates. Moreover, the acute blockade of D(2) receptors in D(3) mutant mice further reduces c-fos expression levels. These data indicate that the basal activity of both D(2) and D(3) receptors contributes to D(1) agonist-stimulated c-fos responses. The findings therefore indicate that not only D(2) but also D(3) receptors play a role in dopamine-regulated gene expression. |
