| First Author | Jang CG | Year | 2003 |
| Journal | Brain Res Mol Brain Res | Volume | 117 |
| Issue | 1 | Pages | 68-72 |
| PubMed ID | 14499482 | Mgi Jnum | J:85653 |
| Mgi Id | MGI:2675910 | Doi | 10.1016/s0169-328x(03)00291-2 |
| Citation | Jang CG, et al. (2003) Impaired water maze learning performance in mu-opioid receptor knockout mice. Brain Res Mol Brain Res 117(1):68-72 |
| abstractText | Previous study has demonstrated that the lack of mu-opioid receptor decreased LTP in the dentate gyrus of the hippocampus, suggesting the possibility that the lack of mu-opioid receptor may accompany a change in learning and memory. However, no behavioral study has been undertaken to correlate LTP deficits with spatial memory impairment in mu-opioid receptor knockout mice. Therefore, the present study investigated the hypothesis that mu-opioid receptors contribute to learning and memory by using the Morris water maze, and comparing responses in wild type and mu-opioid receptor gene knockout mice. Our results indicated that mu-opioid receptor knockout mice showed a significant spatial memory impairment compared to wild type in the Morris water maze. This result suggests that the expression of mu-opioid receptor plays an important role in spatial learning and memory examined by Morris water maze. |
