| First Author | Roy S | Year | 1998 |
| Journal | Brain Res Mol Brain Res | Volume | 56 |
| Issue | 1-2 | Pages | 281-3 |
| PubMed ID | 9602153 | Mgi Jnum | J:72645 |
| Mgi Id | MGI:2153358 | Doi | 10.1016/S0169-328X(98)00051-5 |
| Citation | Roy S, et al. (1998) mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit. Brain Res Mol Brain Res 56(1-2):281-3 |
| abstractText | The role of mu-opioid receptor in gastrointestinal transit was investigated using mu-opioid receptor knockout mice (MOR-KO). Our result establishes unequivocally that inhibition of GI transit by morphine is a mu-opioid receptor mediated function. In addition, we show that neither delta nor kappa receptor agonist given supraspinally or peripherally are able to inhibit GI transit in MOR-KO animals. It was interesting to observe that basal GI motility was lower in MOR-KO (-/-) compared to heterozygous (+/-) and wild type (+/+) animals. |
