| First Author | Liu Q | Year | 2014 |
| Journal | Sci Rep | Volume | 4 |
| Pages | 7554 | PubMed ID | 25523081 |
| Mgi Jnum | J:272276 | Mgi Id | MGI:6214276 |
| Doi | 10.1038/srep07554 | Citation | Liu Q, et al. (2014) Interleukin-17 inhibits adult hippocampal neurogenesis. Sci Rep 4:7554 |
| abstractText | Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions. |
