| First Author | Sigurdardottir S | Year | 2019 |
| Journal | Cell Immunol | Volume | 341 |
| Pages | 103921 | PubMed ID | 31076079 |
| Mgi Jnum | J:281943 | Mgi Id | MGI:6381147 |
| Doi | 10.1016/j.cellimm.2019.04.009 | Citation | Sigurdardottir S, et al. (2019) Diabetes-mediated IL-17A enhances retinal inflammation, oxidative stress, and vascular permeability. Cell Immunol 341:103921 |
| abstractText | Diabetic retinopathy is a prevailing diabetes complication, and one of the leading causes of blindness worldwide. IL-17A is a cytokine involved in the onset of diabetic complications. In the current study, we examined the role of IL-17A in the development of retinal inflammation and long-term vascular pathology in diabetic mice. We found IL-17A expressing T cells and neutrophils in the retinal vasculature. Further, the IL-17A receptor was expressed on Muller glia, retinal endothelial cells, and photoreceptors. Finally, diabetes-mediated retinal inflammation, oxidative stress, and vascular leakage were all significantly lower in IL-17A(-/-) mice. These are all clinically meaningful abnormalities that characterize the onset of diabetic retinopathy. |
