| First Author | Lim VY | Year | 2023 |
| Journal | Life Sci Alliance | Volume | 6 |
| Issue | 4 | PubMed ID | 36717247 |
| Mgi Jnum | J:337979 | Mgi Id | MGI:7431853 |
| Doi | 10.26508/lsa.202301924 | Citation | Lim VY, et al. (2023) Mature B cells and mesenchymal stem cells control emergency myelopoiesis. Life Sci Alliance 6(4) |
| abstractText | Systemic inflammation halts lymphopoiesis and prioritizes myeloid cell production. How blood cell production switches from homeostasis to emergency myelopoiesis is incompletely understood. Here, we show that lymphotoxin-beta receptor (LTbetaR) signaling in combination with TNF and IL-1 receptor signaling in bone marrow mesenchymal stem cells (MSCs) down-regulates Il7 expression to shut down lymphopoiesis during systemic inflammation. LTbetaR signaling in MSCs also promoted CCL2 production during systemic inflammation. Pharmacological or genetic blocking of LTbetaR signaling in MSCs partially enabled lymphopoiesis and reduced monocyte numbers in the spleen during systemic inflammation, which correlated with reduced survival during systemic bacterial and viral infections. Interestingly, lymphotoxin-alpha1beta2 delivered by B-lineage cells, and specifically by mature B cells, contributed to promote Il7 down-regulation and reduce MSC lymphopoietic activity. Our studies revealed an unexpected role of LTbetaR signaling in MSCs and identified recirculating mature B cells as an important regulator of emergency myelopoiesis. |
