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Allele : Ghr<tm1Jjk> growth hormone receptor; targeted mutation 1, John J Kopchick

Primary Identifier  MGI:2388126 Allele Type  Targeted
Attribute String  Null/knockout Gene  Ghr
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  Exon 4 and 500 bp of downstream intronic sequences were replaced with a neomycin resistance cassette via homologous recombination. Northern blot and RT-PCR analysis of liver mRNA from homozygous mutant animals failed to detect gene expression. Western blot analysis of homozygous mutant liver samples did not detect protein product.
  • mutations:
  • Intragenic deletion,
  • Insertion
  • synonyms:
  • GHR-KO,
  • GHR-KO,
  • GHR/BP-,
  • GHR/BP-deficient,
  • Laron dwarf,
  • GHR-,
  • BH-R-KO,
  • GHRko,
  • GHR-,
  • GHR/BP-,
  • GHRko,
  • GHR/BP-deficient,
  • BH-R-KO,
  • Laron dwarf
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

141 Publication categories

Trail: Allele