| First Author | von Bülow GU | Year | 2001 |
| Journal | Immunity | Volume | 14 |
| Issue | 5 | Pages | 573-82 |
| PubMed ID | 11371359 | Mgi Jnum | J:69474 |
| Mgi Id | MGI:1934709 | Doi | 10.1016/s1074-7613(01)00130-3 |
| Citation | von Bulow GU, et al. (2001) Regulation of the T-independent humoral response by TACI. Immunity 14(5):573-82 |
| abstractText | TACI is a TNFR homolog expressed by mature B lymphocytes that has been implicated in the positive regulation of B cell growth and antibody production, as well as in the development of autoimmune disease. Its biology is complex due to the existence of two ligands, BLyS and APRIL, and a homologous receptor, BCMA, that similarly binds both ligands. To determine its critical biological role, we generated TACI knockout mice. Surprisingly, these mice demonstrated a 2-fold increase in numbers of circulating and splenic B cells, apparently due to increased proliferation rate. Maturation of B cells and T-dependent antibody production was normal, but responses to T-independent type II antigens were almost completely abolished. It appears that TACI provides an essential costimulatory signal for the T-independent humoral response. |
