| First Author | Yalcin B | Year | 2004 |
| Journal | Nat Genet | Volume | 36 |
| Issue | 11 | Pages | 1197-202 |
| PubMed ID | 15489855 | Mgi Jnum | J:93903 |
| Mgi Id | MGI:3510091 | Doi | 10.1038/ng1450 |
| Citation | Yalcin B, et al. (2004) Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nat Genet 36(11):1197-202 |
| abstractText | Here we present a strategy to determine the genetic basis of variance in complex phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We show that a commercially available strain of outbred mice, MF1, can be treated as an ultrafine mosaic of standard inbred strains and accordingly used to dissect a known quantitative trait locus influencing anxiety. We also show that this locus can be subdivided into three regions, one of which contains Rgs2, which encodes a regulator of G protein signaling. We then use quantitative complementation to show that Rgs2 is a quantitative trait gene. This combined genetic and functional approach should be applicable to the analysis of any quantitative trait. |
