| First Author | Jain RW | Year | 2018 |
| Journal | Cell Rep | Volume | 25 |
| Issue | 12 | Pages | 3342-3355.e5 |
| PubMed ID | 30566861 | Mgi Jnum | J:270749 |
| Mgi Id | MGI:6278682 | Doi | 10.1016/j.celrep.2018.11.070 |
| Citation | Jain RW, et al. (2018) Autoreactive, Low-Affinity T Cells Preferentially Drive Differentiation of Short-Lived Memory B Cells at the Expense of Germinal Center Maintenance. Cell Rep 25(12):3342-3355.e5 |
| abstractText | B cell fate decisions within a germinal center (GC) are critical to determining the outcome of the immune response to a given antigen. Here, we characterize GC kinetics and B cell fate choices in a response to the autoantigen myelin oligodendrocyte glycoprotein (MOG) and compare the response with a standard model foreign antigen. Both antigens generate productive primary responses, as evidenced by GC development, circulating antigen-specific antibodies, and differentiation of memory B cells. However, in the MOG response, the status of the cognate T cell partner drives preferential B cell differentiation to a memory phenotype at the expense of GC maintenance, resulting in a truncated GC. Reduced plasma cell differentiation is largely independent of T cell influence. Interestingly, memory-phenotype B cells formed in the MOG GC are not long lived, resulting in a failure of the B cell response to secondary challenge. |
