| First Author | Gurevicius K | Year | 2007 |
| Journal | Mol Cell Neurosci | Volume | 34 |
| Issue | 2 | Pages | 189-98 |
| PubMed ID | 17157030 | Mgi Jnum | J:123252 |
| Mgi Id | MGI:3717551 | Doi | 10.1016/j.mcn.2006.10.014 |
| Citation | Gurevicius K, et al. (2007) Increased hippocampal and cortical beta oscillations in mice deficient for the HNK-1 sulfotransferase. Mol Cell Neurosci 34(2):189-98 |
| abstractText | The HNK-1 carbohydrate is detectable in perineuronal nets around inhibitory neurons in the hippocampus and neocortex. To address the functional contribution of HNK-1 to interneuron function in the adult brain, we recorded EEG and auditory-evoked potential in freely moving mice deficient for HNK-1 sulfotransferase (ST-/- mice) and in wild-type littermates. While ST-/- mice displayed normal theta oscillations, both cortical and hippocampal oscillations within the beta range were enhanced, and gamma oscillations showed an opposite trend. ST-/- mice had amplitudes of auditory-evoked potentials similar to control mice, but the latencies of their hippocampal responses were shorter. Morphological analysis revealed a decreased density of parvalbumin-positive interneurons in the hippocampal CA3 subfield of ST-/- mice, which may contribute to the observed changes in networks oscillations. These findings reveal alterations in ST-/- mice that differ from EEG abnormalities of mice deficient in the HNK-1 carrier molecule tenascin-R. |
