| First Author | Luo W | Year | 2018 |
| Journal | Immunity | Volume | 48 |
| Issue | 2 | Pages | 313-326.e5 |
| PubMed ID | 29396161 | Mgi Jnum | J:272358 |
| Mgi Id | MGI:6284432 | Doi | 10.1016/j.immuni.2018.01.008 |
| Citation | Luo W, et al. (2018) B Cell Receptor and CD40 Signaling Are Rewired for Synergistic Induction of the c-Myc Transcription Factor in Germinal Center B Cells. Immunity 48(2):313-326.e5 |
| abstractText | Positive selection of germinal center (GC) B cells is driven by B cell receptor (BCR) affinity and requires help from follicular T helper cells. The transcription factors c-Myc and Foxo1 are critical for GC B cell selection and survival. However, how different affinity-related signaling events control these transcription factors in a manner that links to selection is unknown. Here we showed that GC B cells reprogram CD40 and BCR signaling to transduce via NF-kappaB and Foxo1, respectively, whereas naive B cells propagate both signals downstream of either receptor. Although either BCR or CD40 ligation induced c-Myc in naive B cells, both signals were required to highly induce c-Myc, a critical mediator of GC B cell survival and cell cycle reentry. Thus, GC B cells rewire their signaling to enhance selection stringency via a requirement for both antigen receptor- and T cell-mediated signals to induce mediators of positive selection. |
