| First Author | Okuzawa C | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 371 |
| Issue | 3 | Pages | 561-6 |
| PubMed ID | 18455510 | Mgi Jnum | J:136702 |
| Mgi Id | MGI:3796801 | Doi | 10.1016/j.bbrc.2008.04.124 |
| Citation | Okuzawa C, et al. (2008) Resistance to collagen-induced arthritis in SHPS-1 mutant mice. Biochem Biophys Res Commun 371(3):561-6 |
| abstractText | SHPS-1 is a transmembrane protein that binds the protein tyrosine phosphatases SHP-1 and SHP-2 through its cytoplasmic region and is abundantly expressed on dendritic cells and macrophages. Here we show that mice expressing a mutant form of SHPS-1 fail to develop type-II collagen (CII)-induced arthritis (CIA), a model for rheumatoid arthritis in humans. Histological examinations of the arthritic paws from immunized wild-type mice revealed that cartilage was destroyed in association with marked mononuclear cell infiltration, while only mild cell infiltration was observed in immunized SHPS-1 mutant mice. Consistently, the serum levels of both IgG and IgG2a specific to CII and of IL-1beta in immunized SHPS-1 mutant mice were markedly reduced compared with those apparent for wild-type mice. The CII-induced proliferation of, and production of cytokines by, T cells from immunized SHPS-1 mutant mice were reduced compared to wild-type cells. These results suggest that SHPS-1 is essential for development of CIA. |
