| First Author | Lucas M | Year | 2002 |
| Journal | Eur J Immunol | Volume | 32 |
| Issue | 9 | Pages | 2653-63 |
| PubMed ID | 12207350 | Mgi Jnum | J:78994 |
| Mgi Id | MGI:2386803 | Doi | 10.1002/1521-4141(200209)32:9<2653::AID-IMMU2653>3.0.CO;2-V |
| Citation | Lucas M, et al. (2002) Massive inflammatory syndrome and lymphocytic immunodeficiency in KARAP/DAP12-transgenic mice. Eur J Immunol 32(9):2653-63 |
| abstractText | KARAP/DAP12 is a broadly distributed transmembrane signaling polypeptide with an immunoreceptor tyrosine-based activation motif, and is non-covalently associated with a variety of activating surface receptors. We report here the characterization of transgenic mice that overexpress KARAP/DAP12 polypeptides in both myeloid and lymphoid compartments. KARAP/DAP12-transgenic mice present, in a transgene dose-dependent manner, a complex phenotype characterized by two independent and spontaneous hematological abnormalities: (i) a severe lymphopenia and (ii) a massive inflammatory syndromeassociated with neutrophilia and lung infiltration by multinucleated macrophages. These myeloid abnormalities observed in KARAP/DAP12-transgenic mice indicate that KARAP/DAP12-driven signals are critically involved in inflammation, and constitute an essential target to control the resolution of inflammatory disorders based on monocytes/macrophages and neutrophils. |
