| First Author | Du H | Year | 2018 |
| Journal | PLoS One | Volume | 13 |
| Issue | 8 | Pages | e0200385 |
| PubMed ID | 30089112 | Mgi Jnum | J:266306 |
| Mgi Id | MGI:6196282 | Doi | 10.1371/journal.pone.0200385 |
| Citation | Du H, et al. (2018) MiR-221 negatively regulates innate anti-viral response. PLoS One 13(8):e0200385 |
| abstractText | The innate immune system plays a critical role in the initial antiviral response. However, the timing and duration of these responses must be tightly regulated during infection to ensure appropriate immune cell activation and anti-viral defenses. Here we demonstrate that during antiviral response, a negative regulator miR-221 was also induced in an ELF4-dependent manner. We further show that ELF4 promotes miR-221 expression through direct binding to its promoter. Overexpression and knockdown assay show that miR-221 can negatively regulate IFNbeta production in time of virus infection. RNA-seq analysis of miR-221 overexpressed cells revealed multiple candidate targets. Taken together, our study identified a novel negative microRNA regulator of innate antiviral response, which is dependent on ELF4. |
