| First Author | Pillow JJ | Year | 2001 |
| Journal | J Appl Physiol (1985) | Volume | 91 |
| Issue | 6 | Pages | 2730-4 |
| PubMed ID | 11717240 | Mgi Jnum | J:135119 |
| Mgi Id | MGI:3790391 | Doi | 10.1152/jappl.2001.91.6.2730 |
| Citation | Pillow JJ, et al. (2001) Overexpression of TGF-alpha increases lung tissue hysteresivity in transgenic mice. J Appl Physiol 91(6):2730-4 |
| abstractText | Increased transforming growth factor (TGF)-alpha has been observed in neonatal chronic lung disease. Lungs of transgenic mice that overexpress TGF-alpha develop enlarged air spaces and pulmonary fibrosis compared with wild-type mice. We hypothesized that these pathological changes may alter the mechanical coupling of viscous and elastic forces within lung parenchyma. Respiratory impedance was measured in open-chested, tracheostomized adult wild-type and TGF-alpha mice by using the forced oscillation technique (0.25-19.63 Hz) delivered by flexiVent (Scireq, Montreal, PQ). Estimates of airway resistance (Raw), inertance (I), and the coefficients of tissue damping (G(L)) and tissue elastance (H(L)) were obtained by fitting a model to each impedance spectrum. Hysteresivity (eta) was calculated as G(L)/H(L). There was a significant increase in eta (P < 0.01) and a trend to a decrease in H(L) (P = 0.07) of TGF-alpha mice compared with the wild-type group. There was no significant change in Raw, I, or G(L). Structural abnormality present in the lungs of adult TGF-alpha mice alters viscoelastic coupling of the tissues, as evidenced by a change in eta. |
