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Allele : Bace1<tm1Pcw> beta-site APP cleaving enzyme 1; targeted mutation 1, Philip C Wong

Primary Identifier	MGI:2389228	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Bace1
Transmission	Germline	Strain of Origin	(129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase	false	Is Wild Type	false

molecularNote

Exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot analysis of homozygous mutant embryos.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
BACE1<->,
BACE1<->,
Bace1<->,
Bace1<->

earliestPublication:
Cai H, et al. (2001) BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci 4(3):233-4

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

68 Publication categories

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