| First Author | Favuzzi E | Year | 2017 |
| Journal | Neuron | Volume | 95 |
| Issue | 3 | Pages | 639-655.e10 |
| PubMed ID | 28712654 | Mgi Jnum | J:256086 |
| Mgi Id | MGI:6114457 | Doi | 10.1016/j.neuron.2017.06.028 |
| Citation | Favuzzi E, et al. (2017) Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican. Neuron 95(3):639-655.e10 |
| abstractText | Activity-dependent neuronal plasticity is a fundamental mechanism through which the nervous system adapts to sensory experience. Several lines of evidence suggest that parvalbumin (PV+) interneurons are essential in this process, but the molecular mechanisms underlying the influence of experience on interneuron plasticity remain poorly understood. Perineuronal nets (PNNs) enwrapping PV+ cells are long-standing candidates for playing such a role, yet their precise contribution has remained elusive. We show that the PNN protein Brevican is a critical regulator of interneuron plasticity. We find that Brevican simultaneously controls cellular and synaptic forms of plasticity in PV+ cells by regulating the localization of potassium channels and AMPA receptors, respectively. By modulating Brevican levels, experience introduces precise molecular and cellular modifications in PV+ cells that are required for learning and memory. These findings uncover a molecular program through which a PNN protein facilitates appropriate behavioral responses to experience by dynamically gating PV+ interneuron function. |
