| First Author | Amanna IJ | Year | 2003 |
| Journal | J Immunol | Volume | 170 |
| Issue | 9 | Pages | 4593-600 |
| PubMed ID | 12707337 | Mgi Jnum | J:82993 |
| Mgi Id | MGI:2656417 | Doi | 10.4049/jimmunol.170.9.4593 |
| Citation | Amanna IJ, et al. (2003) Enforced bcl-x(L) Gene Expression Restored Splenic B Lymphocyte Development in BAFF-R Mutant Mice. J Immunol 170(9):4593-600 |
| abstractText | The TNFR family member BAFF-R facilitates peripheral B cell development, although it is unclear whether it promotes survival of B cells, or also initiates a differentiation program. We show that disruption of the BAFF-R encoding gene Tnfrsf13c in strain A/WySnJ mice causes a progressive decline in peripheral B cell numbers, beginning at the transitional 1 developmental stage and continuing through the mature peripheral B cell stage. Bcl-x(L) overexpression in A/WySnJ B cells decreased the turnover of transitional B cells, as determined by 5-bromo-2'-deoxyuridine labeling, and restored follicular B cell development. We conclude that the mutant A/WySnJ allele of Tnfrsf13c can be complemented through the survival signal provided by Bcl-x(L). |
