| First Author | Wojnowski L | Year | 1998 |
| Journal | Mech Dev | Volume | 76 |
| Issue | 1-2 | Pages | 141-9 |
| PubMed ID | 9767153 | Mgi Jnum | J:50696 |
| Mgi Id | MGI:1309594 | Doi | 10.1016/s0925-4773(98)00111-7 |
| Citation | Wojnowski L, et al. (1998) Craf-1 protein kinase is essential for mouse development. Mech Dev 76(1-2):141-9 |
| abstractText | The three mammalian Raf serine/threonine protein kinases mediate the transduction of proliferative and differentiative signals from a variety of cell surface receptors to the nucleus. We report here that Craf-1 is essential for mouse development, as its mutation results in embryonic lethality. Developmental defects are: found in mutant placentas as well as in the skin and in the lungs of mutant embryos. Craf-1 mutants also display a generalized growth retardation which is consistent with the ubiquitous expression of Craf-1 and which could be due to the reduced proliferation of mutant cells. Interestingly, the time-point of embryonal death varies depending on the genetic background. This suggests that Craf-1-mediated signaling is affected by genetic background-specific alleles of other genes. (C) 1998 Elsevier Science Inland Ltd. All rights reserved. |
