| First Author | Bengtsson O | Year | 2001 |
| Journal | Eur J Immunol | Volume | 31 |
| Issue | 9 | Pages | 2652-9 |
| PubMed ID | 11536163 | Mgi Jnum | J:71677 |
| Mgi Id | MGI:2150556 | Doi | 10.1002/1521-4141(200109)31:9<2652::aid-immu2652>3.0.co;2-4 |
| Citation | Bengtsson O, et al. (2001) Maternal kappa-containing IgG induces a late anti-Kappa response in adult, Kappa-deficient offspring. Eur J Immunol 31(9):2652-9 |
| abstractText | Kappa (kappa)-light (L) chain-deficient (Ckappa-/-) mice readily mount a T cell-dependent antibody response after immunization with kappa-containing proteins. Such antibody responses areabsent in normal (Ckappa+/+) animals because of tolerance due to the abundance of kappa-L chains expressed on more than 95% of all B cells and serum immunoglobulins. When heterozygous kappa-sufficient (Ckappa+/-) females are bred with homozygous kappa-deficient (Ckappa-/-) males, half of their offspring will become kappa-deficient but have received kappa-L chain containing maternal Ig, mainly IgG and IgA, through placental and intestinal transmission. The kappa-containing maternal Ig persists for more than 2 months in the circulation of the offspring. Starting from week 15-20 of age, a spontaneous antibody response towards the maternal kappa-L chains can be recorded. The time of onset, as well as the magnitude of the responses differ among individuals of the same litter. Invariably, once a response has been initiated, it transits into an IgG-type of response, which upon injection with kappa-containing protein shows the features of a secondary type of immune response. |
