| First Author | Mita T | Year | 2011 |
| Journal | Biochem Biophys Res Commun | Volume | 415 |
| Issue | 4 | Pages | 545-50 |
| PubMed ID | 22074825 | Mgi Jnum | J:178625 |
| Mgi Id | MGI:5299378 | Doi | 10.1016/j.bbrc.2011.10.086 |
| Citation | Mita T, et al. (2011) IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall. Biochem Biophys Res Commun 415(4):545-50 |
| abstractText | The aim of this study was to investigate the role of insulin receptor substrate-2 (IRS-2) mediated signal in macrophages on the accumulation of macrophages in the vascular wall. Mice transplanted with IRS-2(-/-) bone marrow, a model of myeloid cell restricted defect of IRS-2, showed accumulation of monocyte chemoattractant protein-1-expressing macrophages in the vascular wall. Experiments using cultured peritoneal macrophages showed that IRS-2-mediated signal pathway stimulated by physiological concentrations of insulin, not by IL-4, contributed to the suppression of monocyte chemoattractant protein-1 expression induced by lipopolysaccharide. Our data indicated that IRS-2 deficiency in macrophages enhanced their accumulation in the vascular wall accompanied by increased expression of proinflammatory mediators in macrophages. These results suggest a role for insulin resistance in macrophages in early atherosclerogenesis. |
