| Primary Identifier | MGI:2429994 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Ccr5 |
| Transmission | Germline | Strain of Origin | 129/Sv |
| Is Recombinase | false | Is Wild Type | false |
| description | ES cell line = CJ7 (129S1/Sv-p+ Tyr+ Kitl+) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+). |
| molecularNote | A neomycin selection cassette into exon 2 via homologous recombination replaced sequence encoding all 7 transmembrane domains. Whereas mRNA transcribed from other chemokine (C-C motif) receptor loci was shown to be present at normal levels, endogenous transcript was undetected in homozygous mutant mice by Northern blot analysis. The expression of other CC-chemokine receptor genes, Ccr1, Ccr2, Ccr3, and Ccr4, was not affected. |
