| First Author | Uziel D | Year | 2008 |
| Journal | Neuroreport | Volume | 19 |
| Issue | 8 | Pages | 877-81 |
| PubMed ID | 18463505 | Mgi Jnum | J:136696 |
| Mgi Id | MGI:3796795 | Doi | 10.1097/WNR.0b013e3282ffdeec |
| Citation | Uziel D, et al. (2008) Ephrin-A5 promotes the formation of terminal thalamocortical arbors. Neuroreport 19(8):877-81 |
| abstractText | Ephrins-A5 are expressed in the cortical target layer of thalamic afferents at the time when these axons form terminal arbors. Previous in-vitro studies provided evidence that ephrin-A5 supports the branching of thalamic axons, but there is no direct in-vivo evidence for such a growth-promoting effect. Here we examined thalamocortical projections in ephrins-A5 deficient mice. Our results demonstrate that the laminar specificity of thalamic afferents in ephrin-A5 mutants remains preserved, but axonal arbor formation is greatly reduced. Thus, ephrin-A5 specifically regulates branch formation of thalamic axons, but does not affect target layer selection. Ephrin-A5-mutant mice are, therefore, a unique model to study the effects of reduced thalamic innervation on the assembly of cortical circuits and sensory processing. |
