First Author | DuFort CC | Year | 2016 |
Journal | Cancer Cell | Volume | 29 |
Issue | 6 | Pages | 780-782 |
PubMed ID | 27300433 | Mgi Jnum | J:232330 |
Mgi Id | MGI:5776626 | Doi | 10.1016/j.ccell.2016.05.015 |
Citation | DuFort CC, et al. (2016) Tension and Transformation in Pancreas Cancer: Can Phenotype Break Free from the Chrysalis of Genotype?. Cancer Cell 29(6):780-2 |
abstractText | A recent study finds that impaired TGFbeta signaling can initiate a positive feedback loop between increasing ECM stiffness and epithelial cell contractility in pancreas cancer. Even more surprising is the possibility that this phenotype can liberate the epithelium from dependence on the genetic events that transformed it. |