| First Author | Pucci F | Year | 2016 |
| Journal | Cell Rep | Volume | 17 |
| Issue | 7 | Pages | 1764-1772 |
| PubMed ID | 27829148 | Mgi Jnum | J:240976 |
| Mgi Id | MGI:5896895 | Doi | 10.1016/j.celrep.2016.10.031 |
| Citation | Pucci F, et al. (2016) PF4 Promotes Platelet Production and Lung Cancer Growth. Cell Rep 17(7):1764-1772 |
| abstractText | Co-option of host components by solid tumors facilitates cancer progression and can occur in both local tumor microenvironments and remote locations. At present, the signals involved in long-distance communication remain insufficiently understood. Here, we identify platelet factor 4 (PF4, CXCL4) as an endocrine factor whose overexpression in tumors correlates with decreased overall patient survival. Furthermore, engineered PF4 over-production in a Kras-driven lung adenocarcinoma genetic mouse model expanded megakaryopoiesis in bone marrow, augmented platelet accumulation in lungs, and accelerated de novo adenocarcinogenesis. Additionally, anti-platelet treatment controlled mouse lung cancer progression, further suggesting that platelets can modulate the tumor microenvironment to accelerate tumor outgrowth. These findings support PF4 as a cancer-enhancing endocrine signal that controls discrete aspects of bone marrow hematopoiesis and tumor microenvironment and that should be considered as a molecular target in anticancer therapy. |
