| First Author | Zhang X | Year | 2010 |
| Journal | Nat Neurosci | Volume | 13 |
| Issue | 9 | Pages | 1056-8 |
| PubMed ID | 20676103 | Mgi Jnum | J:165296 |
| Mgi Id | MGI:4836802 | Doi | 10.1038/nn.2610 |
| Citation | Zhang X, et al. (2010) Deletion of the potassium channel Kv12.2 causes hippocampal hyperexcitability and epilepsy. Nat Neurosci 13(9):1056-8 |
| abstractText | We found the voltage-gated K+ channel Kv12.2 to be a potent regulator of excitability in hippocampal pyramidal neurons. Genetic deletion and pharmacologic block of Kv12.2 substantially reduced the firing threshold of these neurons. Kv12.2-/- (also known as Kcnh3-/-) mice showed signs of persistent neuronal hyperexcitability including frequent interictal spiking, spontaneous seizures and increased sensitivity to the chemoconvulsant pentylenetetrazol. |
