| First Author | Reynolds JM | Year | 2015 |
| Journal | Immunity | Volume | 42 |
| Issue | 4 | Pages | 692-703 |
| PubMed ID | 25888259 | Mgi Jnum | J:229778 |
| Mgi Id | MGI:5754452 | Doi | 10.1016/j.immuni.2015.03.008 |
| Citation | Reynolds JM, et al. (2015) Interleukin-17B Antagonizes Interleukin-25-Mediated Mucosal Inflammation. Immunity 42(4):692-703 |
| abstractText | The interleukin-17 (IL-17) family of cytokines has emerged as a critical player in inflammatory diseases. Among them, IL-25 has been shown to be important in allergic inflammation and protection against parasitic infection. Here we have demonstrated that IL-17B, a poorly understood cytokine, functions to inhibit IL-25-driven inflammation. IL-17B and IL-25, both binding to the interleukin-17 receptor B (IL-17RB), were upregulated in their expression after acute colonic inflammation. Individual inhibition of these cytokines revealed opposing functions in colon inflammation: IL-25 was pathogenic but IL-17B was protective. Similarly opposing phenotypes were observed in Citrobacter rodentium infection and allergic asthma. Moreover, IL-25 was found to promote IL-6 production from colon epithelial cells, which was inhibited by IL-17B. Therefore, our data demonstrate that IL-17B is an anti-inflammatory cytokine in the IL-17 family. |
