| First Author | Bordone L | Year | 2007 |
| Journal | Aging Cell | Volume | 6 |
| Issue | 6 | Pages | 759-67 |
| PubMed ID | 17877786 | Mgi Jnum | J:160212 |
| Mgi Id | MGI:4453880 | Doi | 10.1111/j.1474-9726.2007.00335.x |
| Citation | Bordone L, et al. (2007) SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 6(6):759-67 |
| abstractText | We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the beta-actin locus. Mice that are hemizygous for this transgene express normal levels of beta-actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie-restricted diet: they are leaner than littermate controls; are more metabolically active; display reductions in blood cholesterol, adipokines, insulin and fasted glucose; and are more glucose tolerant. Furthermore, transgenic mice perform better on a rotarod challenge and also show a delay in reproduction. Our findings suggest that increased expression of SIRT1 in mice elicits beneficial phenotypes that may be relevant to human health and longevity. |
