| First Author | Delgado P | Year | 2009 |
| Journal | Nat Immunol | Volume | 10 |
| Issue | 8 | Pages | 880-8 |
| PubMed ID | 19561613 | Mgi Jnum | J:151653 |
| Mgi Id | MGI:4354693 | Doi | 10.1038/ni.1749 |
| Citation | Delgado P, et al. (2009) Essential function for the GTPase TC21 in homeostatic antigen receptor signaling. Nat Immunol 10(8):880-8 |
| abstractText | T cell antigen receptors (TCRs) and B cell antigen receptors (BCRs) transmit low-grade signals necessary for the survival and maintenance of mature cell pools. We show here that TC21, a small GTPase encoded by Rras2, interacted constitutively with both kinds of receptors. Expression of a dominant negative TC21 mutant in T cells produced a rapid decrease in cell viability, and Rras2(-/-) mice were lymphopenic, possibly as a result of diminished homeostatic proliferation and impaired T cell and B cell survival. In contrast, TC21 was overexpressed in several human lymphoid malignancies. Finally, the p110delta catalytic subunit of phosphatidylinositol-3-OH kinase (PI(3)K) was recruited to the TCR and BCR in a TC21-dependent way. Consequently, we propose TC21 directly links antigen receptors to PI(3)K-mediated survival pathways. |
