| First Author | Burr KL | Year | 2006 |
| Journal | DNA Repair (Amst) | Volume | 5 |
| Issue | 7 | Pages | 860-2 |
| PubMed ID | 16731053 | Mgi Jnum | J:112191 |
| Mgi Id | MGI:3655776 | Doi | 10.1016/j.dnarep.2006.04.003 |
| Citation | Burr KL, et al. (2006) Elevated mutation rates in the germline of Polkappa mutant male mice. DNA Repair (Amst) 5(7):860-2 |
| abstractText | Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (Polkappa(-/-)) deficient mice. The spontaneous mutation rate in homozygous Polkappa(-/-) males was significantly higher than in isogenic wild-type mice (Polkappa(+/+)), but the ESTR mutation spectrum in Polkappa(-/-) animals did not differ from that in Polkappa(+/+) males. We suggest that compromised translesion synthesis in Polkappa(-/-) mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate. |
